Archive for April, 2009

New insights to fighting colds

April 28th, 2009
flu

achoo!

Researchers who mapped the DNA of more than 100 different cold viruses said recently they have discovered a shortcut in their life cycle, which may explain why they can inflict misery so quickly. They also believe they may be able to design drugs to fight the rhinoviruses, which use their single gene to move rapidly from person to person, causing symptoms that range from irritating sniffles to pneumonia.

Instead of designing one drug to cure the common cold, several may be needed because the virus mutates so efficiently. The hope had been that it might be easy to fight the viruses, which sicken children on average 10 times a year and adults at least twice a year on average.

This is because any rhinovirus has just one gene, which in turn makes a giant protein that appears to do little or nothing until it gets chopped up into 11 smaller pieces by an enzyme called a protease. Researchers tried to attack this big, clumsy protein before it gets chopped up.

The first drug, the virus mutated around it. But now the researchers said now they have all the pieces, they will begin to understand what areas are not so flexible then will begin to do some more rational drug design. For example, it might be possible to attack the protease – an approach that has worked in fighting AIDS.

If the researchers could inhibit the protease from cleaving that protein, maybe they could render all rhinoviruses ineffective.

Bad gums strike at the heart

April 27th, 2009
keep your gums healthy, for a sparkling smile!

keep your gums healthy, for a sparkling smile!

Here’s another reason to brush your teeth – poor dental hygiene poses risk of heart attacks and strokes. Heart disease is the No. 1 killer worldwide, claiming upward of 17 million lives every year according to World Health Organization. Smoking, obesity and high cholestrol are the most common culprits, but new research shows that neglected gums can be added to the list.

Experts now recognize that bacterial infections are an independant risk factors for heart diseases. In other words, it doesn’t matter how fit, slim or healthy you are, you’re adding to your chances of getting heart disease by having bad teeth.

There are up to 700 different bacteria in the human mouth, and failing to scrub one’s pearly whites helps those germs to flourish. Most are benign, and some are essential to good health. But a few can trigger a biological cascade leading to diseases of the arteries linked to heart attacks and stroke, according to the new research.

The mouth is probably the dirtiest place in the human body. If you have an open blood vessel from bleeding gums, bacteria will gain entry to your bloodstream. Once inside the blood, certain bacteria stick onto cells called platelets, causing them to clot inside the vessel and thus decreasing blood flow to the heart.

The scientist mimicked the pressure inside blood vessels and in the heart, and demonstrated that bacteria use different mechanisms to cause platelets to clump together, allowing them to completely encase the bacteria. This not only created conditions that can provoke heart attacks and strokes, it also shielded the bacteria from both immune system cells and antibiotics. These findings suggest why antibiotics do not always work in the treatment of infectious heart disease.

In a separate research, a team led by Greg Seymour of the University of Otago, Dunedin in New Zealand, showed how other bacteria from the mouth can provoke atherosclerosis, a disease that causes hardening of the arteries. All organisms including humans and bacteria produce ’stress proteins’, molecules produced by conditions such as inflammation, toxins, starvation, of oxygen deprivation.

One function of stress proteins is to guide other proteins across cell membranes. But they can also latch onto foreign objects, called antigens, and delivers them to immune cells, provoking an immune reaction in the body. Normally, the body does not attack its own stress proteins. But bacterial stress proteins which are similar to human stress proteins do triggers a response and once that has happened, the immune system can no longer differentiate between the two. White blood cells can build up in the tissue of arteries, causing atherosclerosis.

Have you brush yours?

Have you brush yours?

Should all males be circumsized?

April 27th, 2009

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Some call it genital mutilation. Others, a lifesaving STD stopper ( for men and women ). Whether or not you still have your foreskin, you have a stake in the battle over circumcision. Circumsition, of course is the surgical removal of the penile foreskin from the glans – the fleshy crown of the penis. It is one of the most commonly performed procedures in American hospitals, and except abortion, it may be the most controversial. The procedure has long been known to reduce the spread of a few rare, serious diseases and to prevent a few annoying, uncomfortable ones. But in 1999, the American Academy of Pediatrics (AAP) determined that the risk of surgical complications, though small, nearly canceled out the banefits. They neither discouraged nor recommended the precedure. Since then, 16 states have eliminated. Medicaid coverage for nearly all circumsicions.

But two years ago, a consortium of experts convened by the World Health Organization and UNAIDS ( the United Nations’ HIV program ) announced that circumsicion should indeed “be part of a comprehensive HIV prevention package.” It did so because three separate, meticulous medical trials in Kenya, Uganda and South Africa, involving more than 10,000 men, had proved that circumsicion should reduce the risk of female-to-male HIV infection by approximately 60 percent. This discovery is one that, over the next two decades, could save three million lives in Africa alone.

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Now, no one believes that the potential health benefits for American males are nearly as great or as urgent as they are for men in Africa, where HIV is spread mostly through heterosexual intercourse. Still, similar study results are turning up on this continent, as well. A team of researchers from the CDC, John Hopkins and the Baltimore health department examined the records of more than 1,000 African American males – all heterosexual – who are tested positive for HIV at Maryland clinics. Uncircumsized men were 50 percent more likely to be infected. These result have caused many U.S. doctors to reconsider their positions.

Pain, of course, is the first question that comes to mind whenever the word ‘cut’ and ‘penis’ are used in the same sentence. Ask Marilyn Fayre Milos about pain or better yet don’t. The founder of the National Organizations of Circumcision Information Resource Centers (NOCIRC) first witnessed the procedure in 1979 while training for her nurse’s degree. The unlucky baby, she later wrote, was “strapped spread eagle to a plastic board… struggling against his restraints-tugging, whimmpering and then crying helplessly” while awaiting the knife. Then as doctor began cutting into the penis with a scalpel, ” the baby began to gasp and choked, breathless from his shril continuous screams….” But I think that was in 1979. From what I see back in 2005 in a nursery, it doesn’t look that painful like what had been described.

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Circumsized or not, every man owes his foreskin in a great debt of gratitude for its service in the womb. In the 3rd month of gestation, when the nascent penis begins to bloom, the foreskin forms a little protective blanket under which the rest of the penis can safely grow. But once you and your penis are fully baked, the advantage of a foreskin is not clear. Some scientists speculate that it protected the prehistoric penis as it swung, naked, through thick forest and over tall grasses; and unless you take your penis on that sort of excursion, they argue, you don’t need a foreskin.

That perceived a uselessness may be one reason circumsicion has such a long and varied history. Archeological evidence suggests that the practice may be at least 6,000 years old. Muslims and Jews, along with the aborigines of Australia, the Aztecs and the Mayans of this hemisphere and many other cultures all independently adopted this squirm-inducing practice and it seems unlikely they’d have done so unless they were convinced that it conferred some earthly benefit.

Here in the United States, foreskins were left mostly undisturbed until second half of the 19th century. But it wasn’t until the North Africa campaign of World War II that American doctors turned into enthusiastic circumsicers. More than 145,000 American GIs based there slacked off on their cleaning regimens and came down with foreskin related ouches chiefly balanoposthitis (inflammation of the foreskin and glans), phimosis ( a foreskin too tight to retract over the glans) and paraphimosis (a foreskin stuck in the retracted position). After the war, doctors advanced a theory that circumcision reduces rate of cervical cancer- a hypothesis now confirmed by scientific research.

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Circumcision became routine, but anaesthesia wasn’t part of the plan. That, more than any other factor, may have provoked the fiery anti-circumcision movement that casts its long shadow over the Internet.

So what’s the verdict? Should all males be circumcised? That is for an individual to decide. But whatever you  decide for you and yours, do not let anyone tell you circumcision can’t slow the march of HIV. At a time when billions of American tax dollars are pouring into Africa to fight AIDS, it is extremely important that money is spent on methods that have been proved to help. For millions of men, circumcision could be a matter of life and death.

every safety has its price

every safety has its price